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Partnerships

Expanding AmorphOX through strategic collaborations

Orexo is committed to advancing treatments by combining our proprietary AmorphOX® drug delivery technology with the external expertise of pharmaceutical companies and research organizations to create innovative, scalable solutions that deliver value to patients and partners.

Each bespoke collaboration offers mutually beneficial opportunities

Together with Orexo, partners can bring innovative treatments to the global market efficiently and sustainably in a number of ways:

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Pioneering new formulations that deliver value

AmorphOX transforms existing medications into next-generation products with superior bioavailability, stability, and improved patient experience. Reformulating established drugs opens opportunities for new extensions and additional revenue streams. For example, an existing treatment reformulated with AmorphOX can achieve faster absorption and a longer shelf life, creating new commercial opportunities.

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Broadening therapeutic reach

Augmenting drug delivery, such as through additional routes, may expand use cases to develop additional indications for new patient groups. Making use of, for example the nasal route of administration, can achieve additional therapeutic benefits, such as the successful prevention of pathogen transmission within airborne diseases.

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Rapid onset for critical care

Speed matters in emergencies. The AmorphOX powder dissolves quickly, enabling rapid absorption. This makes it ideal for emergencies, rapid pain relief, and other timesensitive treatments. This positions partner products as best-in-class for fast therapeutic effects.

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Patient-centric drug delivery

Convenience drives adherence. AmorphOX® supports needle-free formats like intranasal powders or oral tablets that quickly dissolve, replacing injections with simple, patient-friendly options. This improves comfort and confidence, enables self-administration, and broadens market adoption opportunities.

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Efficient manufacturing and distribution, enabled by stability

Exceptional stability removes the need for cold-chain logistics, lowering costs and environmental impact. Room-temperature storage streamlines global distribution and supports reliable, scalable manufacturing.

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Extended intellectual property protection

Reformulating with AmorphOX can qualify for new patents, extending exclusivity and securing long-term value. Orexo’s integrated IP strategy ensures robust protection, including multiple patents listed in the FDA’s Orange Book, reinforcing the commercial attractiveness of collaboration.

3 questions to Edward Kim, MD, MBA and Chief Medical Officer at Orexo

What’s the BARDA collaboration?

We have entered a partnership with BARDA to developing a rescue medication, OX390, for overdoses caused by adulterated drugs, such as xylazine. It is supported by AmorphOX, enabling rapid onset, and we will also take advantage of our established supply chain to scale production immediately.

Who is BARDA?

BARDA stands for the Biomedical Advanced Research and Development Authority. It is part of the Administration for Strategic Preparedness and Response (ASPR), which is an agency within the US Department of Health and Human Services.

Can you treat overdoses involving xylazine today?

There are no approved treatments currently where these alpha-2 agonists are mixed with opioids. With that said OX390 has the potential to be the world’s first medical countermeasure (MCM) to the rising threat from alpha 2-agonists.

For questions please contact

SVP Business Development

Raheleh Nassaji

raheleh.nassaji@orexo.com

PhD Scientific Director

Jonas Sävmarker

Director Business Development

Greta Alina Kampe

On maternity leave
March 1–December 31, 2026.

Meet Orexo at the following scientific conferences

June 22-25, 2026 BIO International San Diego, CA

Sep. 16 -17, 2026 IPAC-RS 2026 Nasal Innovation Forum