vorvida® for treatment of alcohol misuse

Short facts

 

Technology

GAIA´s proprietary artificial intelligence (AI)-expert system, broca®

Indication

Heavy alcohol misuse, incl. alcohol use disorder (AUD)

Commercial rights

Orexo owns the exclusive rights to the US market

Partner

In-licensed from GAIA AG

Launch

July, 2020

Key advantages

• Based on Cognitive Behavioral Therapy
• Strong clinical evidence
• Highly individualized
• Standalone treatment or as a complement to traditional pharma treatments


The Concept/Product

vorvida® is a fully automated digital therapy developed by Orexo´s partner GAIA and is based on its proprietary artificial intelligence (AI)-expert system, broca®. vorvida® is scientifically proven to reduce troublesome drinking patterns in adults with AUD.

AUD is a major health crisis affecting approximately 16.6 million people in the United States.Each year, more than 88,000 people die from alcohol-related causes,2 making it the third leading preventable cause of death in the country. Alcohol misuse costs the United States about USD 249 billion per year.3

Clinical Data

In a randomized controlled trial involving 608 adults with problematic alcohol intake, researchers found that participants in the intervention group with vorvida® significantly reduced their daily alcohol consumption over three and six months, with significant effect sizes.4 Additionally, in comparison to the control group, vorvida® users reported fewer days of binge drinking and drunkenness while stating high acceptance and utility rates of vorvida® at the same time.

Substance Abuse and Mental Health Services Administration (SAMHSA).
Sacks, J.J.; Gonzales, K.R.; Bouchery, E.E.; Tomedi, L.E.; and Brewer, R.D. 2010 National and state costs of excessive alcohol consumption. American Journal of Preventive Medicine49(5):e73–e79, 2015.
Substance Abuse and Mental Health Services Administration (SAMHSA). Results from the 2017 National Survey on Drug Use and Health: Detailed Tables. Table 5.5A—Alcohol Use Disorder in Past Year Among Persons Aged 12 or Older, by Age Group and Demographic Characteristics: Numbers in Thousands, 2016 and 2017. https://www.samhsa.gov/data/sites/default/files/cbhsq-reports/NSDUHDetailedTabs2017/NSDUHDetailedTabs2017. htm.
4 Jördis M. Zill, Eva Christalle, Björn Meyer, Martin Härter, and Jörg Dirmaier The Effectiveness of an Internet Intervention Aimed at Reducing Alcohol Consumption in Adults: Results of a Randomized Controlled Trial (Vorvida) Dtsch Arztebl Int 2019; 116: 127–33. DOI: 10.3238/arztebl.2019.0127